Progesterone receptor ligands for the treatment of endometriosis.

Estrogen dependence and progesterone resistance play a crucial role in the origin and development of endometriosis. Therefore, hormonal therapies are currently the most effective treatment. Progestins are considered the first-line approach, especially for a long-term management. Progestins are synthetic compounds that mimic the effects of progesterone by binding progesterone receptors. Continuous use of progestins leads to the suppression of ovarian steroidogenesis with anovulation and low serum levels of ovarian steroids, causing endometrial pseudodecidualization. Moreover, they act by interfering on several endometriosis pathogenetic pathways, decreasing inflammation, provoking apoptosis in endometriotic cells, stimulating atrophy or regression of endometrial lesions, inhibiting angiogenesis, and decreasing expression of metalloproteinases, thus diminishing the invasiveness of endometriotic implants. Progestins are effective for pain relief and improvement of the quality of life (QoL). The side effects are limited, and the compounds are available in different formulations and routes of administration and represent, in most cases, an inexpensive treatment option. Dienogest, Medroxyprogesterone acetate and Norethisterone acetate are the labeled progestins for endometriosis, but other progestins, such as Dyhidrogesterone, Levonorgestrel and Desogestrel, have been shown to be effective in the treatment of endometriosis-associated pain. The present review aims to describe the available and emerging evidences on progestins used for the treatment of endometriosis.

Cost, microbiological, and nutritional properties of pureed food production in nursing homes. The ABADIA Study / Propiedades nutricionales, microbiológicas y costes de producción de las dietas de textura modificada en las residencias de ancianos. El estudio ABADÍA

Introduction: although nutritional differences between different types of texture-modified diet (TMD) have been evaluated, the resources and costs associated with their preparation have been less studied. Objective: to describe the nutritional, microbiological properties and costs of: 1) in-home produced pureed food (hTMD); 2) concentrated nutrient-dense commercial food products, hand-blended (cTMD); 3) food prepared using the MixxPro® automatic food mixer (cTMD-Mix). Methods: an observational, prospective study carried out in three geriatric nursing-homes. Patients ≥ 65 years, receiving TMD, with a stable clinical condition, estimated survival/expected internment > 1 month, and sufficient cognitive capacity were included. The following data were recorded: 1) patient socio-demographic and clinical variables; 2) TMD compliance and symptoms related to dysphagia during the meal; 3) patient appetite; and 4) kitchen information and resources used to prepare a TMD. Results: sixty-two residents were included (65.0 % women, 88.3 years (SD: 9.3); 43.5 % malnourished, 79.0 % with good appetite). The proportion of food eaten/median kcal served/portion/mean kcal consumed were: hTMD: 95.5 % (SD: 10.7)/92.4 kcal (IQR: 75.6-128.1)/88.2 kcal (IQR: 72.2-122.3); cTMD: 89.2 % (SD: 15.9)/323.4 kcal (IQR: 284.2-454.1)/288.5 kcal (IQR: 253.5-325.1); and cTMD-Mix: 80.3 % (SD: 21.4)/358.0 kcal (IQR: 344.0-372.1)/287.5 kcal (IQR: 276.5-298.8). No microorganisms were detected. The average time spent in preparing each portion and its costs were: hTMD: 11.2 min (SD: 3.89)/€2.33 (SD: 0.63); cTMD: 1.7 min (SD: 0.28)/€2.01 (SD: 0.39); and cTMD-Mix: 1.6 min (SD: 0.00)/€2.00 (SD: 0.33). (AU)

Introducción: aunque existe evidencia acerca de las diferencias nutricionales entre los distintos tipos de dieta de textura modificada (DTM), los recursos y los costos asociados a su preparación se han estudiado menos.Objetivo: describir las propiedades nutricionales, las microbiológicas y los costes de: 1) una dieta triturada de manera artesanal (hDTM); 2) una dieta preparada con alimentación básica adaptada (ABA) (cDTM); y 3) una ABA preparada con el mezclador automático de alimentos MixxPro® (cDTM-Mix). Métodos: estudio observacional prospectivo realizado en tres residencias. Se incluyeron pacientes ≥ de 65 años que recibían DTM, con estado clínico estable, con supervivencia/internamiento estimado > 1 mes y capacidad cognitiva suficiente. Se registraron: 1) las variables sociodemográficas y clínicas del paciente; 2) el cumplimiento y los síntomas relacionados con la disfagia durante la comida; 3) el apetito del paciente, y 4) la información de la cocina y los recursos utilizados para preparar la DTM. Resultados: se incluyeron 62 residentes (65,0 % mujeres, 88,3 años (SD: 9,3), 43,5 % desnutridos, 79,0 % con buen apetito). La proporción de alimentos consumidos/mediana de kcal servidas/porción/media de kcal media consumidas fueron: hDTM 95,5 % (SD: 10,7)/92,4 kcal (IQR: 75,6-128,1)/88,2 kcal (IQR: 72,2-122,3); cDTM: 89.2 % (SD: 15.9)/323,4 kcal (IQR: 284.2-454.1)/288,5 kcal (IQR: 253.5-325.1), y cDTM-Mix: 80,3 % (SD: 21.4)/358,0 kcal (IQR: 344.0-372.1)/287,5 kcal (IQR: 276.5-298.8). No se detectaron microorganismos. El tiempo medio empleado en la preparación y el coste por porción fueron: hDTM: 11,2 min (SD: 3,89)/2,33 € (SD: 0,63); cDTM: 1,7 min (SD: 0,28)/2,01 € (SD: 0,39), y cDTM-Mix: 1,6 min (SD: 0,00)/2,00 € (SD: 0,33). (AU)

Cost, microbiological, and nutritional properties of pureed food production in nursing homes. The ABADIA Study.

INTRODUCTION: Introduction: although nutritional differences between different types of texture-modified diet (TMD) have been evaluated, the resources and costs associated with their preparation have been less studied. Objective: to describe the nutritional, microbiological properties and costs of: 1) in-home produced pureed food (hTMD); 2) concentrated nutrient-dense commercial food products, hand-blended (cTMD); 3) food prepared using the MixxPro® automatic food mixer (cTMD-Mix). Methods: an observational, prospective study carried out in three geriatric nursing-homes. Patients ≥ 65 years, receiving TMD, with a stable clinical condition, estimated survival/expected internment > 1 month, and sufficient cognitive capacity were included. The following data were recorded: 1) patient socio-demographic and clinical variables; 2) TMD compliance and symptoms related to dysphagia during the meal; 3) patient appetite; and 4) kitchen information and resources used to prepare a TMD. Results: sixty-two residents were included (65.0 % women, 88.3 years (SD: 9.3); 43.5 % malnourished, 79.0 % with good appetite). The proportion of food eaten/median kcal served/portion/mean kcal consumed were: hTMD: 95.5 % (SD: 10.7)/92.4 kcal (IQR: 75.6-128.1)/88.2 kcal (IQR: 72.2-122.3); cTMD: 89.2 % (SD: 15.9)/323.4 kcal (IQR: 284.2-454.1)/288.5 kcal (IQR: 253.5-325.1); and cTMD-Mix: 80.3 % (SD: 21.4)/358.0 kcal (IQR: 344.0-372.1)/287.5 kcal (IQR: 276.5-298.8). No microorganisms were detected. The average time spent in preparing each portion and its costs were: hTMD: 11.2 min (SD: 3.89)/€2.33 (SD: 0.63); cTMD: 1.7 min (SD: 0.28)/€2.01 (SD: 0.39); and cTMD-Mix: 1.6 min (SD: 0.00)/€2.00 (SD: 0.33). Conclusions: in patients with dysphagia and/or chewing difficulties, concentrated nutrient-dense food products, particularly those produced using the MixxPro® automatic food mixer, ensure a high caloric intake and allow quick and safe food preparation.

INTRODUCCIÓN: Introducción: aunque existe evidencia acerca de las diferencias nutricionales entre los distintos tipos de dieta de textura modificada (DTM), los recursos y los costos asociados a su preparación se han estudiado menos. Objetivo: describir las propiedades nutricionales, las microbiológicas y los costes de: 1) una dieta triturada de manera artesanal (hDTM); 2) una dieta preparada con alimentación básica adaptada (ABA) (cDTM); y 3) una ABA preparada con el mezclador automático de alimentos MixxPro® (cDTM-Mix). Métodos: estudio observacional prospectivo realizado en tres residencias. Se incluyeron pacientes ≥ de 65 años que recibían DTM, con estado clínico estable, con supervivencia/internamiento estimado > 1 mes y capacidad cognitiva suficiente. Se registraron: 1) las variables sociodemográficas y clínicas del paciente; 2) el cumplimiento y los síntomas relacionados con la disfagia durante la comida; 3) el apetito del paciente, y 4) la información de la cocina y los recursos utilizados para preparar la DTM. Resultados: se incluyeron 62 residentes (65,0 % mujeres, 88,3 años (SD: 9,3), 43,5 % desnutridos, 79,0 % con buen apetito). La proporción de alimentos consumidos/mediana de kcal servidas/porción/media de kcal media consumidas fueron: hDTM 95,5 % (SD: 10,7)/92,4 kcal (IQR: 75,6-128,1)/88,2 kcal (IQR: 72,2-122,3); cDTM: 89.2 % (SD: 15.9)/323,4 kcal (IQR: 284.2-454.1)/288,5 kcal (IQR: 253.5-325.1), y cDTM-Mix: 80,3 % (SD: 21.4)/358,0 kcal (IQR: 344.0-372.1)/287,5 kcal (IQR: 276.5-298.8). No se detectaron microorganismos. El tiempo medio empleado en la preparación y el coste por porción fueron: hDTM: 11,2 min (SD: 3,89)/2,33 € (SD: 0,63); cDTM: 1,7 min (SD: 0,28)/2,01 € (SD: 0,39), y cDTM-Mix: 1,6 min (SD: 0,00)/2,00 € (SD: 0,33). Conclusiones: en los pacientes con disfagia y/o dificultades para masticar, los productos de ABA comerciales, en particular los que se producen con el mezclador automático de alimentos MixxPro®, aseguran una elevada ingesta calórica y permiten una preparación rápida y segura.

Predictors of mediastinal staging and usefulness of pet in patients with stage IIIA (N2) or IIIB (N3) lung cancer.

OBJECTIVE: To analyze which factors predict mediastinal N2/N3 lymph node staging and diagnostic accuracy of PET and CT to determine it. PATIENTS AND METHODS: We analyzed data collected prospectively in a database that included patients with non-small cell lung cancer (NSCLC) who underwent EBUS-TBNA. Prior to EBUS-TBNA, CT and PET were used to define the radiographic N stage and lymph nodes with short axis ≥ 1 cm by CT or with ratio between maximum standardized uptake value (maxSUV), by PET, of lymph node and primary tumor greater than 0.56, were considered pathological. Definitive lymph node staging was established through EBUS-TBNA, mediastinoscopy or surgical lymph node dissection. RESULTS: One hundred and thirty four patients were included, in 88 of whom (65.6%), definitive lymph node staging was N2 or N3. Primary tumor of central location, lymph node size, maxSUV of lymph node and radiographic N stage by CT or PET were associated with N2/N3 in univariate analysis, but in logistic regression model it was only independently related with N stage by CT or PET. Negative predictive value and positive predictive value of CT were 0.81 and 0.74, respectively, and for PET 0.78 and 0.68. CONCLUSION: In NSCLC, in locoregional disease radiographic staging by CT or PET predict the existence of N2/N3 mediastinal disease, but negative and positive predictive values of both imaging techniques are not adequate, so EBUS-TBNA samples should be taken in all lymph nodes with a diameter greater than 5 mm, regardless of PET findings.

¿Puede un programa de investigación en tuberculosis promovido por una sociedad científica contribuir al control de la enfermedad? / Can a tuberculosis research program promoted by a scientific society contribute to the control of the disease?

A pesar de que España es un país desarrollado, la tuberculosis (TB) fue durante años una enfermedad con importantes tasas de incidencia con respecto a otros países europeos, situación que empeoró con la epidemia del VIH/SIDA y el aumento de la inmigración. Como consecuencia de la situación, SEPAR crea en el año 2004 los Programas Integrados de Investigación (PII), entre los que se incluye la TB (PII-TB). Dicho programa ha llevado a cabo estudios relacionados con alguna de las cinco líneas de investigación que éste mantiene: clínica/epidemiológica, microbiológica, tecnológica/gestión clínica, evaluativa y de cooperación internacional. Siguiendo las recomendaciones sobre la necesidad de evaluar los programas de salud que hacen los organismos internacionales, se realizó recientemente la evaluación del PII-TB, lo que ha permitido conocer la situación de las principales variables de la enfermedad a lo largo de los años de funcionamiento del programa y la evolución de las mismas. El PII-TB ha generado abundantes datos sobre la situación de esta enfermedad en nuestro país durante unos años en que esta información ha sido limitada. El hecho de que los resultados de los estudios hayan sido extensamente difundidos, facilita que todos los profesionales implicados en la prevención, diagnóstico y tratamiento de la TB puedan implementar y/o mejorar las actividades que, en definitiva, contribuirán a mejorar el control de esta enfermedad

Although Spain is a developed country, Tuberculosis (TB) was for years a disease with high incidence rates compared to other European countries, a situation that worsened with the HIV/AIDS epidemic and with the increase of immigration. The Spanish Respiratory Society (SEPAR) created in 2004 the Integrated Research Programs (PII) on respiratory diseases, including TB (PII-TB) which has carried out studies related to the five lines of research that it maintains: clinical / epidemiological, microbiological, technological/clinical management, evaluative, and international cooperation. Following the recommendations on the necessity to evaluate health programs made by international organizations, the evaluation of PII-TB was recently carried out, revealing the situation of the main variables of the disease and their evolution over the time that the program has been working. PII-TB has generated abundant data on the situation of this disease in our country in years when this information has been limited. The fact that the results of the studies have been widely disseminated makes it easier for all professionals involved in the prevention, diagnosis and treatment of TB to implement and/or to improve activities that, finally, will contribute to the control of this disease

Control de la pérdida de velocidad a través dela escala de esfuerzo percibido en press de banca / Control of the velocity loss through the scale of perceived effort in bench press

Controlar las variables de entrenamiento es vital para garantizar las adaptaciones deseadas en el entrenamiento de fuerza, siendo la intensidad especialmente importante para mejorar la fuerza máxima y el RFD. La velocidad de ejecución ha resultado ser la mejor variable para monitorizar la intensidad del entrenamiento de fuerza, en particular las pérdidas de velocidad relacionadas con la fatiga. Sin embargo, existen impedimentos materiales para poder utilizar esta variable. Por tanto, el objetivo de este trabajo es analizar la relación entre el RPE y las pérdidas de velocidad como alternativa para controlar el entrenamiento. Se midió a 5 sujetos (4 hombres y 1 mujer) pertenecientes a la selección española de lucha libre olímpica un total de 15 series de press de banca (3 series/sujeto), de las cuales solo 14 se incluyeron en el análisis estadístico por incumplir una de ellas el protocolo, con 3 cargas relativas distintas (5 series/carga) y una pérdida de velocidad entre 20%-32%. Las variables dependientes fueron: RPE, la pérdida de velocidad, el número de repeticiones realizadas en cada serie y velocidad de la mejor repetición de cada serie. Se analizaron las correlaciones entre las variables RPE-pérdida de velocidad; RPE-número de repeticiones; RPE-velocidad mejor repetición, obteniéndose solamente correlación significativa (r Pearson 0,843; P < 0,001) entre el RPE y la pérdida de velocidad; la correlaciones entre el RPE-número de repeticiones y RPE-velocidad mejor repetición no mostraron significación estadística. Estos resultados podrían indicar la posibilidad de gestionar la fatiga y la intensidad del entrenamiento utilizando la relación RPE-pérdida de velocidad, aunque es necesario llevar a cabo estudios similares con tamaños muestrales mayores que refuercen los resultados obtenidos en este estudio

Controlling the training variables is vital to ensure the desired adaptations in resistance training; intensity is the most important variable to improve maximum strength and rate of force development (RFD). The movement velocity has shown to be the best variable to monitor the intensity of resistance training, in particular the velocity loss related to fatigue. However, there are material impediments to use this variable. Therefore, the aim of this paper is to analyze the relationship between RPE and velocity losses as an alternative to control training. Sample included 5 subjects (4 men and 1 woman) from the Spanish Olympic Wrestling team who performed a total of 15 sets of bench press (3 set/subject), of which only 14 were included in the statistical analysis for breaching one of them the protocol, with 3 different relative loads (5 set/load) and a velocity loss between 20%-32%. The dependent variables were: RPE, the velocity loss, the number of repetitions performed in each set and the velocity of the best repetition of each set. The correlations between the RPE-velocity loss; RPE-number of repetitions; and RPE-velocity best repetition variables were analyzed, obtaining only significant correlation (r Pearson 0.843, P < 0.001) between the RPE and the velocity loss; correlations between RPE-number of repetitions; and RPE-velocity best repetition did not show statistical significance . The results of the present work could indicate the possibility of managing fatigue and controlling training intensity using the RPE-velocity loss relationship, although it is necessary to carry out similar studies with larger sample sizes that reinforce the results of this study

Decision tree learning to predict overweight/obesity based on body mass index and gene polymporphisms.

The new technologies for data analysis, such as decision tree learning, may help to predict the risk of developing diseases. The aim of the present work was to develop a pilot decision tree learning to predict overweight/obesity based on the combination of six single nucleotide polymorphisms (SNP) located in feeding-associated genes. Genotype study was performed in 151 healthy individuals, who were anonymized and randomly selected from the TALAVERA study. The decision tree analysis was performed using the R package rpart. The learning process was stopped when 15 or less observation was found in a node. The participant group consisted of 78 men and 73 women, who 100 individuals showed body mass index (BMI) ≥ 25 kg/m2 and 51 BMI < 25 kg/m2. Chi-square analysis revealed that individuals with BMI ≥ 25 kg/m2 showed higher frequency of the allelic variation Ala67Ala in AgRP rs5030980 with respect to those with BMI <25 kg/m2. However, the variant Thr67Ala in AgRP rs5030980 was the most frequently found in individuals with BMI <25 kg/m2. There were no statistical differences in the other analyzed SNPs. Decision tree learning revealed that carriers of the allelic variants AgRP (rs5030980) Ala67Ala, ADRB2 (rs1042714) Gln27Glu or Glu27Glu, INSIG2 (rs7566605) 73 + 9802 with CC or GG genotypes and PPARG (rs1801282) with the allelic variants of Ala12Ala or Pro12Pro, will most likely develop overweight/obesity (BMI ≥ 25 kg/m2). Moreover, the decision tree learning indicated that age and gender may change the developed three decision learning associated with overweight/obesity development. The present work should be considered as a pilot demonstrative study to reinforce the broad field of application of new data analysis technologies, such as decision tree learning, as useful tools for diseases prediction. This technology may achieve a potential applicability in the design of early strategies to prevent overweight/obesity.

Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction.

RATIONALE: Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cleaners and in persons cleaning at home has been reported. Long-term consequences of cleaning agents on respiratory health are, however, not well described. OBJECTIVES: This study aimed to investigate long-term effects of occupational cleaning and cleaning at home on lung function decline and airway obstruction. METHODS: The European Community Respiratory Health Survey (ECRHS) investigated a multicenter population-based cohort at three time points over 20 years. A total of 6,235 participants with at least one lung function measurement from 22 study centers, who in ECRHS II responded to questionnaire modules concerning cleaning activities between ECRHS I and ECRHS II, were included. The data were analyzed with mixed linear models adjusting for potential confounders. MEASUREMENTS AND MAIN RESULTS: As compared with women not engaged in cleaning (ΔFEV1 = -18.5 ml/yr), FEV1 declined more rapidly in women responsible for cleaning at home (-22.1; P = 0.01) and occupational cleaners (-22.4; P = 0.03). The same was found for decline in FVC (ΔFVC = -8.8 ml/yr; -13.1, P = 0.02; and -15.9, P = 0.002; respectively). Both cleaning sprays and other cleaning agents were associated with accelerated FEV1 decline (-22.0, P = 0.04; and -22.9, P = 0.004; respectively). Cleaning was not significantly associated with lung function decline in men or with FEV1/FVC decline or airway obstruction. CONCLUSIONS: Women cleaning at home or working as occupational cleaners had accelerated decline in lung function, suggesting that exposures related to cleaning activities may constitute a risk to long-term respiratory health.

Recursos de salud positiva: estudio exploratorio con grupos del ámbito escolar de Pamplona / Positive health resources: exploratory study with groups from the Pamplona school area

No disponible

The surface modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) copolymers to improve the attachment of urothelial cells.

Biocompatible and biodegradable poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(HB-co-HHx)] substrates were modified to improve the attachment of porcine urothelial cell culture. The pristine copolymer exhibits excellent mechanical properties to replace the bladder tissue, but its surface lacks chemical functionalities to interact with cells. Thus, wet chemical treatments based on NaOH and ethylenediamine in aqueous [ED(aq)] and isopropanol [ED(isoOH)] media to functionalize the P(HB-co-HHx) films surfaces were compared. Among these treatments, short ED(aq) treatment was able to decrease the hydrophobicity, rendering a surface with amino groups and without a significant alteration of the mechanical properties. Furthermore, to enhance the interaction with urothelial cells, laminin derived YIGSR sequence was covalently bound to these amino functionalized substrates. The focal attachment was clearly improved with this last treatment, comparing with those results found with the unmodified and first-step functionalized P(HB-co-HHx).

A predictive scoring instrument for tuberculosis lost to follow-up outcome.

BACKGROUND: Adherence to tuberculosis (TB) treatment is troublesome, due to long therapy duration, quick therapeutic response which allows the patient to disregard about the rest of their treatment and the lack of motivation on behalf of the patient for improved. The objective of this study was to develop and validate a scoring system to predict the probability of lost to follow-up outcome in TB patients as a way to identify patients suitable for directly observed treatments (DOT) and other interventions to improve adherence. METHODS: Two prospective cohorts, were used to develop and validate a logistic regression model. A scoring system was constructed, based on the coefficients of factors associated with a lost to follow-up outcome. The probability of lost to follow-up outcome associated with each score was calculated. Predictions in both cohorts were tested using receiver operating characteristic curves (ROC). RESULTS: The best model to predict lost to follow-up outcome included the following characteristics: immigration (1 point value), living alone (1 point) or in an institution (2 points), previous anti-TB treatment (2 points), poor patient understanding (2 points), intravenous drugs use (IDU) (4 points) or unknown IDU status (1 point). Scores of 0, 1, 2, 3, 4 and 5 points were associated with a lost to follow-up probability of 2,2% 5,4% 9,9%, 16,4%, 15%, and 28%, respectively. The ROC curve for the validation group demonstrated a good fit (AUC: 0,67 [95% CI; 0,65-0,70]). CONCLUSION: This model has a good capacity to predict a lost to follow-up outcome. Its use could help TB Programs to determine which patients are good candidates for DOT and other strategies to improve TB treatment adherence.

Surface modification of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer films for promoting interaction with bladder urothelial cells.

Often bladder dysfunction and diseases lead to therapeutic interventions that require partial or complete replacement of damaged tissue. For this reason, the development of biomaterials to repair the bladder by promoting the adhesion and growth of urothelial cells is of interest. With this aim, a modified copolyester of biocompatible and biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(HB-co-HV)] was used as scaffold for porcine urothelial cell culture. In addition to good biocompatibility, the surface of P(HB-co-HV) substrates was modified to provide both, higher hydrophilicity and a better interaction with urothelial cells. Chemical treatments with ethylenediamine (ED) and sodium hydroxide (NaOH) led to substrate surfaces with decreasing hydrophobicity and provided functional groups that enable the grafting of bioactive molecules, such as a laminin derived YIGSR sequence. Physico-chemical properties of modified substrates were studied and compared with those of the pristine P(HB-co-HV). Urothelial cell morphology on treated substrates was studied. The results showed that focal attachment and cell-related properties were improved for peptide grafted polymer compared with both, the unmodified and functionalized copolyester.

Adecuación del aislamiento respiratorio e influencia del tratamiento en lamicrobiología del esputo en pacientes con tuberculosis / No disponible

Objetivo: Evaluar la adecuación del aislamiento y la respuesta microbiológica al tratamiento en pacientes con tuberculosis (TB).Métodos: Determinaciones: 1. Adecuación del aislamiento: hospitalario (sospecha diagnóstica y aislamiento desde la admisión en la planta de hospitalización) o domiciliario (diagnóstico y tratamiento tras el alta en urgencias y aislamiento en el domicilio 15 días). 2. Influencia del tratamiento en el estado bacteriológico del esputo. Resultados: 1. De 100 pacientes consecutivos con TB, 50 tenían baciloscopia +, 37 de ellos tenían aislamiento correcto (28 hospitalario, 9 domiciliario). En los 13 restantes el aislamiento fue incorrecto,3 domiciliario (dos alta sin aislamiento y retraso diagnóstico de 7 y 10 días, otro con aislamiento 10días) y 10 ingresados (retraso de 1-14 días, media 4.5; en 5 retraso de un día y en los 5 restantes retraso de 3 a 14 días). 2. De 50 pacientes con baciloscopia + en 14 se realizó control microbiológicoal mes del inicio del tratamiento (todos baciloscopia +, 10 cultivo +). En 25 con control al 2º mes, 8baciloscopia +, 7 Cultivo +.Conclusiones: 1. Se ha objetivado que en el 13% de los pacientes con TB no se realizó el aislamiento correctamente. 2. En pacientes con TB bacilífera, tras uno o dos meses de tratamiento existe un número importante con baciloscopia y cultivo +. Se deben controlar la política de aislamiento y la respuesta microbiológica al tratamiento por la influencia que pueden tener en la transmisión de la TB (AU)

Aim: To know 1º. The respiratory isolation policy, 2º. The effect of treatment on the sputum bacteriologic status in patients with tuberculosis (TB).Methods: 1. Description of isolation policies. We defined correct isolation in hospital as diagnosis suspicion and isolation on admission and duration no less than 15 days and correct domiciliary isolation as diagnosis in emergency room with recommendation of treatment and stay at home at least 15days. 2. Follow-up of sputum status after treatment. Results: 1. 100 consecutive patients, sputum smear + in 50, 37 with correct isolation (28 in hospital and 9 domiciliary). In 13 with incorrect isolation, 3 were outpatients (2 without diagnosis neither isolation and delay in diagnosis of 7 and 10 days and another with domiciliary isolation of 10 days). In10 inpatients the diagnosis delay was 1 to 14 days (mean 4.5). 2. Fifty positive smear patients were followed-up for bacteriology controls. First month control on 14 showed positive smear for all and positive culture for 10 of them. Second month control was performed on 25, 8 of them were smear positive and 7 culture positive. Conclusions: 1. In 13% of patients with TB we did not perform the isolation correctly. 2. There was a high rate of positives smear and culture after one and two months of treatment within TB patients with initial positive smear. We must control isolation policy and bacteriologic response to treatment because of the influence that can have in TB transmission (AU)

Variables sociodemográficas y síndrome de burnout en una muestra multiocupacional del Hospital Psiquiátrico Penitenciario de Sevilla / No disponible

Se estudia la relación entre las variables sociodemográficas y el síndrome de quemarsepor el trabajo (burnout) en una muestra compuesta por 136 trabajadores del HospitalPsiquiátrico Penitenciario de Sevilla (el 93% de la población total) que fueron divididos entres subgrupos en función de la categoría profesional (vigilantes, tratamiento y servicios)y el nivel de contacto con los internos. Los resultados muestran que los trabajadores quetenían un mayor nivel de contacto se mostraban significativamente menos satisfechoscon su desempeño profesional y se encontraban más despersonalizados que el resto, dela misma manera que los trabajadores adscritos al área de vigilancia en relación a losparticipantes asignados al área de tratamiento y servicios. Se comprueba también que lasmujeres y los que poseían un nivel de estudio universitario estaban menos despersonalizados.Así mismo, se muestra que los trabajadores que tenían un solo hijo estaban másdespersonalizados y agotados emocionalmente que el resto de trabajadores

This study aims to assess the relationship between sociodemographic variable andthe burnout syndrome in a multiocupational sample of the Hospital Psychiatric Prison ofSeville. The sample consisted of 136 workers of the Hospital Psychiatric Prison (93%of the total staff) that were gathered in three groups (security, services and treatment)their level of contact with the inmates was also taked into account. Results show that prison employees with high levels of contact with the inmates experience higher levelsof depersonalization and were less satisfied with their personal accomplishment at workthan the personnel with less contact. Significant differences were also found among thethree groups (security, services and treatment). Depersonalization and low personalaccomplishment were higher in the security officer’s group. On the other hand, lowerlevels of depersonalization were found between women and personnel with universitystudies. This study also shows that to have an only child is positively related to depersonalization and emotional exhaustion (AU)

Validez factorial del Maslach Burnout Inventory (MBI) en una muestra de trabajadores del Hospital Psiquiátrico Penitenciario de Sevilla / Factorial Validity of the Maslach Burnout Inventory (MBI) in a sample of workers of the Hospital Psychiatric Prison of Seville

Este estudio explora la estructura factorial de una adaptación al castellano del Maslach Burnout Inventory (MBI) en una muestra compuesta por 136 trabajadores del Hospital Psiquiátrico Penitenciario de Sevilla, desde vigilantes hasta psiquiatras. Se efectuó un análisis factorial mediante componentes principales con rotación varimax que presentó cinco factores con autovalores mayores que uno. En el primer factor se agruparon los ítems de agotamiento emocional, en el segundo los de despersonalización, y en los factores tres, cuatro y cinco los ítems de realización personal en el trabajo. Con posterioridad se realizó otro análisis ajustando a tres la extracción de factores. La solución factorial reprodujo la distribución de los ítems del manual, aunque los ítems seis, catorce y dieciséis saturaban en más de una subescala. A tenor de los resultados obtenidos y de las conclusiones ofrecidas en estudios similares, el cuestionario se puede considerar válido y fiable en la versión adaptada al castellano en la muestra objeto de estudio

This study was designed to assess the structures of the Maslach Burnout Inventory (MBI) for 136 professional of Hospital Psychiatric Prison of Seville, from prison officers to psychiatrist. Responses were factor analysed using principal components and a Varimax rotation. Exploratory factor analysis offered five factors with eigenvalues exceeding unity. Items offer Emotional Exhaustion loaded on Factor I, items of DeperIV and Factor V. A second factor analysis was carried out with a specification to extract three factors. This factor analysis showed a factor structure consistent with the original. However, items 6, 14 and 16 loaded on Emotional Exhaustion and Depersonalisation dimensions. As a whole, results show that the MBI appears to be valid and reliable for Spanish prison professionals